The Lowy Packer Building houses the Victor Chang Cardiac Research Institute and the St Vincent's Centre for Applied Medical Research (AMR), which came into existence in 2008 and incorporates the Clinical Research Program (CRP). The AMR-CRP provides a high quality clinical trials service across the Darlinghurst campus.

The St Vincent's Centre for Applied Medical Research (AMR) has a long and proud tradition of conducting research with the aim of improving outcomes for those with or at risk of disease. In October 2008, the Centre for Immunology and the Clinical Trials Unit from St Vincent's Hospital merged to form AMR. The Centre for Immunology was established in 1983 and was the first of its kind in New South Wales and the second in Australia.

St Vincent's Centre for Applied Medical Research forms part of St Vincent's Hospital and is the primary research flagship of the St Vincent's Group. AMR conducts clinical, applied and translational research with a focus on immunology, HIV and infectious diseases, neurosciences, transplantation biology and cancer.

St Vincent's Centre for Applied Medical Research had an exceptional year in 2010/2011, in realising many of the operational efficiencies that were anticipated through collocation and building critical mass with its partners, the Kirby Institute, HIV Immunovirology Program and the Clinical Research Program. Together these groups have implemented a model to efficiently manage their shared essential services. This includes centralising scientific stores and supplies, cryogenic stores, glassware and media preparation services, back-of-house services including waste management, engineering and maintenances, services, medical grade gases and loading dock operations.