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As well as Research Program Head at St Vincent’s Centre of Applied Medical Research, Sam Breit is a Clinical Immunologist and Immunopathologist at St Vincent’s Hospital, Sydney and Professor of Medicine at University of New South Wales. The research activities of his Group are centred around the biology, role in disease pathogenesis and clinical application of two molecules that were first cloned and characterised by his laboratory in the 1990’s, on the basis of their increased expression with macrophage activation:
The TGF-b superfamily cytokine MIC-1/GDF15.
The intracellular chloride ion channel CLIC1.
Current Research Projects
- The role of MIC-1/GDF15 in the biology of cancer
- The mechanism of action of MIC-1/GDF15 in appetite regulation
- The role of MIC-1/GDF15 in chronic inflammatory diseases
- The mechanism of action of CLIC1 in control of chronic inflammatory processes
- Structure/function of CLIC1
Opportunities for PhD and other higher degree research students Prof Breit has a long track training record in training PhD and other research students. Positions are available for suitably qualified students to undertake laboratory based research within Prof Breit’s group. Such research would be focused around the group’s current project areas and would be negotiated on an individual basis.
Additional top-up funding is also often available for PhD students that already have a basic level of funding from Universities or other funding bodies. For enquiries, please see contact information, below.
Publications View selected publications for MIC-1/GDF15 and CLIC1
PubMed publications for Professor Breit
External Funding Agencies NHMRC ARC Cancer Council NSW Prostate Cancer Foundation of Australia
Licensed discoveries
Measurement of serum levels of MIC-1/GDF15 for prognosis and management of cardiovascular diseases has been licensed to Hoffman La Roche.
MIC-1/GDF15 for treatment of obesity and chronic inflammatory diseases has been licensed to Novo Nordisk AG.
Licensing opportunities Anti-MIC-1/GDF15 therapy for anorexia/cachexia of cancer and other diseases.
Measurement of serum levels of MIC-1/GDF15 for prognosis and management of cancer.
Current Laboratory Members Lab Head Samuel Breit
Postdoctoral Fellows Lele Jiang Yasmin Husaini Vicky Wang-Wei Tsai Liyun Wu
Research Assistants Tamara Kuffner Michelle Lee-Ng Hui Li Glen Lockwood Ping Shang Hong Ping Zhang
Graduate students Kanin Salao Xu Wei Luo
Administrative support Anna Irvine
Contact Information T: +61 (0)2 8382 4952 F: +61 (0)2 8382 4965 E:
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