 The Applied Neurosciences Program led by Professor Bruce J. Brew is a translational research program dedicated to an improved understanding of chronic neurological and neurodegenerative disorders such as Multiple Sclerosis, HIV-associated Neurocognitive Disorders, Alzheimer’s disease; Parkinson Disease and stroke. By utilising a multi-disciplinary approach, the research program involves an array of new techniques in field of neurobiology, stem cell biology, neuroimmunology, neurovirology and neuropsychology.For additional information, see Prof. Brew's UNSW Website.
The research program has five main axes, each led by senior researchers/clinicians.
Neurosciences - Stem Cells Group
(Juliana Lamoury, Ph.D.)
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Adult stem cells and their application to neurodegenerative disorders.
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Tryptophan metabolism in stem cell biology and neurogenesis.
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Role of chemokines in adult stem cell migration.
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For additional information, see Dr. Lamoury's UNSW Website.
Neurodegenerative Diseases Group
(Gilles Guillemin, Ph.D.)
- Involvement of quinolinic acid and other trypthophan catabolites in the pathogenesis of Alzheimer’s disease
- The kynurenine pathway in the pathogenesis of amyotrophic lateral sclerosis (ALS)
- NAD+ Metabolism in Aging and Degenerative Diseases
- Neuroprotective effects of Natural compounds on ADF/cofilin-actin rod formation in human primary neurons
- More information here
For additional information, see Dr. Guillemin's UNSW Website
HIV Neurosciences Group
(Lucette Cysique, Ph.D. & Bruce Brew, MBBS MD FRACP)
- Immunological, virological and neuro-inflammatory markers associated with HIV-associated Neurocognitive Disorders progression
- Neurocognitive functioning and its association with immunological and virological markers
- Brain macro-structure (MRI; DTI) and brain metabolism (MRS) and its association with immunological and virological markers
- Brain aging in HIV-associated Neurocognitive Disorders
- Neurocognitive functioning and antiretroviral treatment
- More information here
For additional information, see Dr. Cysique's UNSW Website.
Parkinson and Movement Disorders Group
(Stephen Tisch MBBS PhD FRACP and Paul Darveniza MBBS MD FRACP)
- Parkinson’s disease subthalamic nucleus and pallidal deep brain stimulation Apomorphine treatment
- Dystonia, pallidal deep brain stimulation, botulinum toxin
- Spasmodic dysphonia, laryngeal botulinum toxin injection, laryngeal EMG
- Tremor deep brain stimulation, posterior subthalamic area deep brain stimulation
- Post stroke and cerebral palsy spasticity clinic, botulinum toxin
- Clinical neurophysiology, movement disorders neurophysiology
Stroke Group
(Romesh Markus, MBChB PhD FRACP)
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Imaging the Ischaemic Penumbra using MRI, CT and PET
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Reperfusion strategies for the treatment of acute ischaemic stroke
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Extension of the time window for ischaemic stroke thrombolysis using imaging surrogates
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Prehospital epidemiology of acute stroke
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Implementation of acute stroke thrombolysis in NSW including telethrombolysis
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Stroke recovery – early rehabilitation
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Stroke prevention
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Assessment of cognitive and mood changes after stroke and their imaging correlates
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Prevalence of Fabry’s disease in cryptogenic stroke
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Last Updated on Friday, 03 December 2010 09:37 |
