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Herbert Herzog

Professor Herbert Herzog is Conjoint Professor at UNSW and currently holds a National Health and Medical Research Council of Australia Research Investigator (L3) grant.

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Research Program: Metabolism and Eating Disorders Research Program

Metabolism and Eating Disorders Research Program

Bio

Professor Herbert Herzog is Conjoint Professor at UNSW and currently holds a National Health and Medical Research Council of Australia Research Investigator (L3) grant. Prof. Herzog studied Chemistry, switching to Biochemistry for his PhD, which he obtained from the University of Innsbruck (Austria) in 1989. In 1991, he moved to Sydney where he studies the role of NPY and other family members like PYY and pancreatic polypeptide, investigating the numerous different functions of these molecules in various physiological settings. He has published his findings on NPY and related neuropeptides in over 330 articles which are cited over 28,000 times. Prof. Herzog’s current work focuses on determining the fundamental processes that can lead to the development of obesity, or the other extreme anorexia, especially investigating the brain's role in the regulation of eating behaviour, stress and glucose homeostasis. He is also interested in how homeostatic processes that regulate bodyweight are coordinated with other homeostatic processes in the body, like the one that controls bone and fat mass, and how these effects change with age.

PublicationsSelected Publications from Herbert Herzog

  • Targeting the NPY/NPY1R signaling axis in mutant p53-dependent pancreatic cancer impairs metastasis. Chambers CR, Watakul S, Schofield P, Howell AE, Zhu J, Tran AMH…….. Herzog H*, Timpson P*, Herrmann D*. Sci Adv. 2025 Mar 14;11(11):eadq4416. doi: 10.1126/sciadv.adq4416. Epub 2025 Mar 12. PMID: 40073121 *equal last.
  • Impact of non-sugar sweeteners on metabolism beyond sweet taste perception. Herzog H, Zhang L, Fontana L, Neely GG. Trends Endocrinol Metab. 2024 Nov 16:S1043-2760(24)00276-5. doi: 10.1016/j.tem.2024.10.008. Online ahead of print.
  • Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism. Pierre JF, Peters BM, La Torre D, Sidebottom AM, Tao Y, Zhu X, Cham CM, Wang L, Kambal A, Harris KG, Silva JF, Zaborina O, Alverdy JC, Herzog H, Witchley J, Noble SM, Leone VA, Chang EB. Science. 2023 Aug 4;381(6657):502-508. doi: 10.1126/science.abq3178. Epub 2023 Aug 3. PMID: 37535745
  • Critical role of lateral habenula circuits in the control of stress-induced palatable food consumption. Ip CK, Rezitis J, Qi Y, Bajaj N, Koller J, Farzi A, Shi YC, Tasan R, Zhang L, Herzog H. Neuron. 2023 Aug 16;111(16):2583-2600.e6. doi: 10.1016/j.neuron.2023.05.010. Epub 2023 Jun 8. PMID: 37295418
  • Agrp-negative arcuate NPY neurons drive feeding under positive energy balance via altering leptin responsiveness in POMC neurons. Qi Y, Lee NJ, Ip CK, Enriquez R, Tasan R, Zhang L, Herzog H. Cell Metab. 2023 Jun 6;35(6):979-995.e7. doi: 10.1016/j.cmet.2023.04.020. Epub 2023 May 17. PMID: 37201523